pentobarbital will lessen the level or impact of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers lessens plasma concentration of abemaciclib and its metabolites.Sleeplessness is issues in falling or remaining asleep, the absence of restful